The SINFONIA (Radiation risk appraisal for detrimental effects from medical exposure during management of patients with lymphoma or brain tumour) project is a research project funded by the European Commission. Its main objective is to develop novel methodologies and tools that will provide comprehensive risk appraisal for detrimental effects from radiation exposure to patients, workers, carers and comforters, the public and the environment during the management of patients suspected or diagnosed with lymphoma and brain tumours. Personalised dosimetry methods and AI-assisted tools to estimate the radiation burden to patients undergoing imaging and radiation therapy procedures for diagnosis, staging, treatment response and follow-up are currently being developed. A computational system for real-time dose assessment of nuclear medicine staff is also under development. The impact on human and biota from the release of radiopharmaceuticals by hospitals is being assessed by developing appropriate transport models. Research work is in progress to determine the degree of intra- and inter-individual variability for the risk of developing second malignant neoplasms (SMNs) after radiotherapy and validate functional and genetic biomarkers of susceptibility to SMNs. Data will be collected in a shared depository. A training programme is currently being developed to train young clinicians, medical physicists, radiobiologists and other healthcare professionals as a team. More information can be found at

Facts and figures

Project acronym: SINFONIA

End date: August 31, 2024

Scientific coordinator: Prof. John Damilakis

Project Coordinator: EIBIR (European Institute for Biomedical Imaging Research)

Consortium: 14 partners from 8 European countries

Total funding: € 5 999 997,50